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Siepel Lab |

Threading a sequence through an ancestral recombination graph (Rasmussen et al., 2014). Drosophila heat shock factor strongly prefers to bind in a strict manner at two pentamers and in a relaxed manner at the third (Guertin, Martins et al., 2012). Position-specific selection at GATA2 binding sites in the human genome (Gronau et al., 2013). Complex evolutionary history of the PRAME gene cluster in humans, chimpanzees, and rhesus macaques (Rhesus Macaque Genome Sequencing Consortium, 2007).

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Siepel Lab | | siepellab.labsites.cshl.edu Reviews

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Threading a sequence through an ancestral recombination graph (Rasmussen et al., 2014). Drosophila heat shock factor strongly prefers to bind in a strict manner at two pentamers and in a relaxed manner at the third (Guertin, Martins et al., 2012). Position-specific selection at GATA2 binding sites in the human genome (Gronau et al., 2013). Complex evolutionary history of the PRAME gene cluster in humans, chimpanzees, and rhesus macaques (Rhesus Macaque Genome Sequencing Consortium, 2007).

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Siepel Lab | | siepellab.labsites.cshl.edu Reviews

https://siepellab.labsites.cshl.edu

Threading a sequence through an ancestral recombination graph (Rasmussen et al., 2014). Drosophila heat shock factor strongly prefers to bind in a strict manner at two pentamers and in a relaxed manner at the third (Guertin, Martins et al., 2012). Position-specific selection at GATA2 binding sites in the human genome (Gronau et al., 2013). Complex evolutionary history of the PRAME gene cluster in humans, chimpanzees, and rhesus macaques (Rhesus Macaque Genome Sequencing Consortium, 2007).

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siepellab.labsites.cshl.edu

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Siepel Lab | Press

http://siepellab.labsites.cshl.edu/press

Press on Human / Neanderthal Interbreeding. Game of Genomes, Episode Eleven: The Neanderthal Inside. By Carl Zimmer, July 26, 2016. In Neanderthals’ DNA, Ancient Humans May Have Left Genetic Mark. Nytimes.com, February 17, 2016. Neanderthals and modern humans mated 50,000 years earlier than we thought, scientists say. CSMonitor.com, Feb 17, 2016. Humans and Neanderthals may have interbred 50,000 years earlier than previously thought. WashingtonPost.com Feb 17, 2016. CSHL, February 17, 2016.

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Siepel Lab | People

http://siepellab.labsites.cshl.edu/people

Asiepel at cshl dot edu. Adam Siepel is a Professor in the Watson School of Biological Sciences. And Chair of the Simons Center for Quantitative Biology. Yihuang at cshl dot edu. Aplatts at cshl dot edu. Rramani at cshl dot edu. Ndukler at cshl dot edu. Bgulko at cs dot cornell dot edu. Mjhubisz at cornell dot edu. Ehutton at cshl dot edu. Lp364 at cornell dot edu. Gill at cshl dot edu. Postdoc, 2010 2013). Natural selection on transcription factor binding sites in recent human evolution. Leo was...Postd...

3

Siepel Lab | Publications

http://siepellab.labsites.cshl.edu/publications

And Castellano S. 2016. Ancient gene flow from early modern humans into Eastern Neanderthals. Danko C. G., Hyland S. L., Core L. J., Martins A. L., Waters C. T., Lee H. W., Cheung V. G., Kraus W. L., Lis J. T., and Siepel, A. 2015 Identification of active transcriptional regulatory elements from GRO-seq data. Gulko, B., Hubisz, M. J., Gronau, I., and Siepel, A. 2015 A method for calculating probabilities of fitness consequences for point mutations across the human genome. Nat Genet.,. Nat Genet.,. 2013 I...

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Siepel Lab | Jobs

http://siepellab.labsites.cshl.edu/jobs

See NEW openings for postdoctoral associates in Computational Genomics. Or visit the CSHL Careers. Students interested in Ph.D. positions should apply to the Watson School of Biological Sciences. Cold Spring Harbor Laboratory’s graduate program. It is also possible to join the laboratory via the Ph.D. programs in Computer Science at Stony Brook University. And Computational Biology and Medicine at Weill Cornell. Page last updated 17 Mar 2016].

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blog.languager.org

Languager: Mechanism Romanticism and the Origins of the Computer

http://blog.languager.org/2016/07/mechanism-romanticism-computers.html

Machine – Imperates. Programmer – Declarates. Language – Relevates. Wednesday, July 27, 2016. Mechanism Romanticism and the Origins of the Computer. Guest Article: Reposted with thanks. The origins of the electronic computer…. Between 1910 and 1913, which in its attempt to place mathematics squarely in the domain of logic, represented the first new system of logic since Aristotle (Pagels, 1989; Dyson, 1997). In 1928, Hilbert posed three questions designed to answer explicitly whether it was possible to d...

keinanlab.cb.bscb.cornell.edu

People | Keinan Lab

http://keinanlab.cb.bscb.cornell.edu/content/people

Recent and Selected Publications. Alon Keinan's NCBI MyBibliography (pubmed). Two new postdoctoral positions available in the lab. Release of a much improved X chromosome analysis toolsest (XWAS v1.1). Our paper on selection of a vegetarian allele piqued the interest of many in the media. Alon Keinan to teach Coalescent Theory and Human Population Genomics. Upcoming presentations at ASHG 2015. New software: EGGS efficiently estimates sfs for generalized-growth demography models. Liams research interests ...

siepellab.org

About | Siepel lab

https://siepellab.org/about

Thoughts on genomics, evolution, gene regulation and other things. Simons Center for Quantitative Biology. Cold Spring Harbor Laboratory. Leave a Reply Cancel reply. Enter your comment here. Fill in your details below or click an icon to log in:. Address never made public). You are commenting using your WordPress.com account. ( Log Out. You are commenting using your Twitter account. ( Log Out. You are commenting using your Facebook account. ( Log Out. Notify me of new comments via email.

compgen.cshl.edu

PHAST: Home

http://compgen.cshl.edu/phast

Conservation scoring and identification of conserved elements. Log-odds scoring for phylogenetic models or phylo-HMMs. Fitting of phylogenetic models to aligned DNA sequences. Computation of p-values for conservation or acceleration, either lineage-specific or across all branches. Prediction of elements under lineage-specific selection. Probabilistic reconstruction of ancestral sequences. Identification of GC-biased gene conversion using a phylo-HMM. Send feedback to: phasthelp@cshl.edu. And also on CRAN.

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siepellab.labsites.cshl.edu

Siepel Lab |

Threading a sequence through an ancestral recombination graph (Rasmussen et al., 2014). Drosophila heat shock factor strongly prefers to bind in a strict manner at two pentamers and in a relaxed manner at the third (Guertin, Martins et al., 2012). Position-specific selection at GATA2 binding sites in the human genome (Gronau et al., 2013). Complex evolutionary history of the PRAME gene cluster in humans, chimpanzees, and rhesus macaques (Rhesus Macaque Genome Sequencing Consortium, 2007).

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Siepel lab | Thoughts on genomics, evolution, gene regulation and other things

Thoughts on genomics, evolution, gene regulation and other things. A Short History of Quantitative Biology at Cold Spring Harbor Laboratory. A Short History of Quantitative Biology at Cold Spring Harbor Laboratory. Delbruck and Luria relaxing at Cold Spring Harbor. Rich Roberts at CSHL in 1975. The Hillside Campus at CSHL, home to the Simons Center for Quantitative Biology. For a number of years, quantitative biology research continued in the absence of a designated unit, but in 2008, the Center for Quan...

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