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Siepel lab | Thoughts on genomics, evolution, gene regulation and other thingsThoughts on genomics, evolution, gene regulation and other things
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Siepel lab | Thoughts on genomics, evolution, gene regulation and other things | siepellab.org Reviews
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Thoughts on genomics, evolution, gene regulation and other things
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Author post: Probabilities of Fitness Consequences for Point Mutations Across the Human Genome | Siepel lab
http://siepellab.org/2014/11/08/author-post-probabilities-of-fitness-consequences-for-point-mutations-across-the-human-genome
Thoughts on genomics, evolution, gene regulation and other things. Author post: Probabilities of Fitness Consequences for Point Mutations Across the Human Genome. November 8, 2014. This article originally appeared as a guest post. Dated September 12, 2014. It is re-posted here for completeness.). This guest post is by Adam Siepel. On his group’s paper Gulko et al. Probabilities of Fitness Consequences for Point Mutations Across the Human Genome. Four Genomicists in a Subaru. The Problem of Grouping.
Letter to Greg Cooper | Siepel lab
http://siepellab.org/2015/01/19/letter-to-greg-cooper
Thoughts on genomics, evolution, gene regulation and other things. Letter to Greg Cooper. January 19, 2015. Email to Gregory Cooper sent July 26, 2014, cc’d to Jay Shendure, Martin Kircher, Brad Gulko, and Ilan Gronau]. I’ve copied Brad Gulko and Ilan Gronau, who have been the leads in my group on the fitCons project. In any case, there’s no point in having a philosophical discussion about the costs and benefits of alternative modeling approaches when they can be compared empirically. The proof...Your va...
Our Paper: Genome-wide inference of ancestral recombination graphs | Siepel lab
http://siepellab.org/2014/11/08/our-paper-genome-wide-inference-of-ancestral-recombination-graphs
Thoughts on genomics, evolution, gene regulation and other things. Our Paper: Genome-wide inference of ancestral recombination graphs. November 8, 2014. This article originally appeared as a guest post. On Haldane’s Sieve. Dated July 2, 2013. It is re-posted here for completeness.). This guest post is by Adam Siepel. On his paper with Matthew Rasmussen. Rasmussen and Siepel Genome-wide inference of ancestral recombination graphs. Inference of Ancestral Recombination Graphs. What is the ARG? The problem w...
FitCons Method Published in Nature Genetics and Rebuttal to Cooper et al.’s Critique (‘Don’t be a CADD’) | Siepel lab
http://siepellab.org/2015/01/19/fitcons-method-published-in-nature-genetics-and-rebuttal-to-cooper-et-al-s-critique-dont-be-a-cadd
Thoughts on genomics, evolution, gene regulation and other things. FitCons Method Published in Nature Genetics and Rebuttal to Cooper et al.’s Critique (‘Don’t be a CADD’). January 19, 2015. Our paper on our new computational method for computing probabilities of fitness consequences for point mutations in the human genome, originally released as a preprint on the bioRxiv. Appeared online today in. As I described in an earlier blog post. Let me begin with my perspective on the background for this critique.
adamsiepel | Siepel lab
http://siepellab.org/author/adamsiepel
Thoughts on genomics, evolution, gene regulation and other things. A Short History of Quantitative Biology at Cold Spring Harbor Laboratory. March 2, 2015. A Short History of Quantitative Biology at Cold Spring Harbor Laboratory. Delbruck and Luria relaxing at Cold Spring Harbor. Rich Roberts at CSHL in 1975. The Hillside Campus at CSHL, home to the Simons Center for Quantitative Biology. For a number of years, quantitative biology research continued in the absence of a designated unit, but in 2008, the ...
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Threading a sequence through an ancestral recombination graph (Rasmussen et al., 2014). Drosophila heat shock factor strongly prefers to bind in a strict manner at two pentamers and in a relaxed manner at the third (Guertin, Martins et al., 2012). Position-specific selection at GATA2 binding sites in the human genome (Gronau et al., 2013). Complex evolutionary history of the PRAME gene cluster in humans, chimpanzees, and rhesus macaques (Rhesus Macaque Genome Sequencing Consortium, 2007).
Siepel lab | Thoughts on genomics, evolution, gene regulation and other things
Thoughts on genomics, evolution, gene regulation and other things. A Short History of Quantitative Biology at Cold Spring Harbor Laboratory. A Short History of Quantitative Biology at Cold Spring Harbor Laboratory. Delbruck and Luria relaxing at Cold Spring Harbor. Rich Roberts at CSHL in 1975. The Hillside Campus at CSHL, home to the Simons Center for Quantitative Biology. For a number of years, quantitative biology research continued in the absence of a designated unit, but in 2008, the Center for Quan...
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