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TUBEROUSSCLEROSIS.ORG

TuberousSclerosis.org

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TUBERIN蛋白質複合體 (protein complex) 的活性。在此以Group-based Prediction System (GPS 2.1) 分析TUBERIN的胺基酸序列中,可能被AKT磷酸化的位置。結果顯示TUBERIN的Ser939、Ser1130與Thr1462很可能會受AKT磷酸化。其中Ser939與Thr1462已被證實會受AKT磷酸化,且TUBERIN的活性將因此而被抑制。 TUBERIN蛋白質複合體 (protein complex) 的活性。在此以Group-based Prediction System (GPS 2.1) 分析HAMARTIN的胺基酸序列中,可能被AKT磷酸化的位置。結果顯示HAMARTIN蛋白質無明顯會被AKT磷酸化的可能位置,由此可推測AKT主要調控的對象可能是TUBERIN蛋白質。 TUBERIN-Pattern and profile search. 藉由MotifScan ( http:/ myhits.isb-sib.ch/cgi-bin/motif scan. HAMARTIN-Pattern and profile search.

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